Abstract:
The elevated incidence of cardiovascular diseases and deaths among individuals with type 2
diabetes mellitus cannot be solely attributed to the prevalent conventional cardiac risk factors. It
is plausible that fibrinogen and platelets might contribute to this augmented risk. The objective
of this research endeavor is to examine the association between fibrinogen and platelet levels in
type 2 diabetes mellitus patients, along with their interconnection with glycemic management.
For this study, 146 T2DM subjects were matched with 146 controls of the same age and sex. The
fibrinogen levels of all participants were measured and correlated with various parameters such
as fasting blood sugar, age, and sex. The results showed that patients with type 2 diabetes
mellitus had higher plasma fibrinogen levels (3.55±1.24) compared to controls (2.69±0.85).
Additionally, the cases group had a higher mean platelet count (399.02±362.55) compared to
controls (281.09±125.98).
The study also compared the fibrinogen levels and platelet counts of patients with "Good" and
"Poor" glycemic control. The "Poor" glycemic control group had a higher mean fibrinogen level
of 4.50 compared to the "Good" group (3.5). However, statistical analysis showed that the
observed difference in fibrinogen levels between these groups may not be statistically significant
at the 5% level (p-value = 0.123). A similar pattern emerged for platelet counts, with the "Poor"
group having a higher mean count (419.60) than the "Good" group (310.45).
According to the study, there may be a separate relationship between platelet counts and
fibrinogen levels and fasting blood sugar levels. This finding adds credence to the theory that
fibrinogen may be a key factor in the elevated risk of thrombotic and cardiovascular events in
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people with type 2 diabetes mellitus. The study's conclusions are important because they may
help uncover possible biomarkers for the early identification and prevention of type 2 diabetes
complications
